RecName: Full=Lysosomal alpha-mannosidase; Short=Laman; AltName: Full= - Protein

Run BLAST
Find regions of similarity between this sequence and other sequences using BLAST.
Identify Conserved Domains
View conserved domains detected in this protein sequence using CD-search.
Highlight Sequence Features
Opens the Highlight Feature Bar and highlights feature annotations from the FEATURES table of the record. The Highlight Feature Bar can be used to navigate to and highlight other features and provides links to display the highlighted region separately. Links in the FEATURES table will also highlight the corresponding region of the sequence. More...
Find in this Sequence
Finds sub-sequences or patterns in the sequence and highlights the matching regions. The tool works with standard single letter nucleotide or protein codes including ambiguities and can match Prosite patterns in protein sequences. More...

White matter alteration and cerebellar atrophy are hallmarks of brain MRI in alpha-mannosidosis. [Mol Genet Metab. 2021]
White matter alteration and cerebellar atrophy are hallmarks of brain MRI in alpha-mannosidosis.
Majovska J, Nestrasil I, Paulson A, Nascene D, Jurickova K, Hlavata A, Lund T, Orchard PJ, Vaneckova M, Zeman J, et al. Mol Genet Metab. 2021 Mar; 132(3):189-197. Epub 2020 Dec 3.
Hearing impairment as an early sign of alpha-mannosidosis in children with a mild phenotype: Report of seven new cases. [Am J Med Genet A. 2019]
Hearing impairment as an early sign of alpha-mannosidosis in children with a mild phenotype: Report of seven new cases.
Lehalle D, Colombo R, O'Grady M, Héron B, Houcinat N, Kuentz P, Moutton S, Sorlin A, Thevenon J, Delanne J, et al. Am J Med Genet A. 2019 Sep; 179(9):1756-1763. Epub 2019 Jun 26.
Recognition of alpha-mannosidosis in paediatric and adult patients: Presentation of a diagnostic algorithm from an international working group. [Mol Genet Metab. 2019]
Recognition of alpha-mannosidosis in paediatric and adult patients: Presentation of a diagnostic algorithm from an international working group.
Guffon N, Tylki-Szymanska A, Borgwardt L, Lund AM, Gil-Campos M, Parini R, Hennermann JB. Mol Genet Metab. 2019 Apr; 126(4):470-474. Epub 2019 Jan 31.

RefSeq genomic sequence
See the genomic reference sequence for the MAN2B1 gene (NG_008318.1).
RefSeq protein isoforms
See 6 reference sequence protein isoforms for the MAN2B1 gene.

PubMed
PubMed articles cited by protein sequence record
Taxonomy
Taxonomy sequences associated with protein record
BioAssay by Target (Summary)
BioAssay by Target (Summary)
BioSystems
BioSystems
CDD Search Results
Display conserved domains within a protein
Conserved Domains (Concise)
Link to a concise list of conserved domains in a protein
Conserved Domains (Full)
Link to conserved domains within a protein
Domain Relatives
Display proteins with similar conserved domain architecture
Full text in PMC
Free full text articles in PMC
Gene
Link to related Genes
OMIM
OMIM records associated with protein sequence
Protein (RefSeq)
Protein gi (UniProtKB) to protein gi (refseq)
PubMed (Weighted)
Links to pubmed
Related Structures (List)
List of related structures
Related Structures (Summary)
Related structures

O00754 [Domain Mapping of Disease Mut...]
O00754
Domain Mapping of Disease Mutations
Transcript/Protein Information [PANTHER Classification System]
Transcript/Protein Information
PANTHER Classification System
Reactome [Reactome]
Reactome
reagents [ExactAntigen/Labome]
reagents
ExactAntigen/Labome

RecName: Full=Lysosomal alpha-mannosidase; Short=Laman; AltName: Full=Lysosomal ...
RecName: Full=Lysosomal alpha-mannosidase; Short=Laman; AltName: Full=Lysosomal acid alpha-mannosidase; AltName: Full=Mannosidase alpha class 2B member 1; AltName: Full=Mannosidase alpha-B; Contains: RecName: Full=Lysosomal alpha-mannosidase A peptide; Contains: RecName: Full=Lysosomal alpha-mannosidase B peptide; Contains: RecName: Full=Lysosomal alpha-mannosidase C peptide; Contains: RecName: Full=Lysosomal alpha-mannosidase D peptide; Contains: RecName: Full=Lysosomal alpha-mannosidase E peptide; Flags: Precursor
gi|118574274|sp|O00754.3|MA2B1_HUMA

Protein

Your browsing activity is empty.

Activity recording is turned off.

Protein