RecName: Full=Thioredoxin reductase 1, cytoplasmic; Short=TR; AltName: - Protein

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Therapeutic targeting of thioredoxin reductase 1 causes ferroptosis while potentiating anti-PD-1 efficacy in head and neck cancer. [Chem Biol Interact. 2024]
Therapeutic targeting of thioredoxin reductase 1 causes ferroptosis while potentiating anti-PD-1 efficacy in head and neck cancer.
Hsieh MS, Ling HH, Setiawan SA, Hardianti MS, Fong IH, Yeh CT, Chen JH. Chem Biol Interact. 2024 May 25; 395:111004. Epub 2024 Apr 16.
Synergistic targeting of TrxR1 and ATM/AKT pathway in human colon cancer cells. [Biomed Pharmacother. 2024]
Synergistic targeting of TrxR1 and ATM/AKT pathway in human colon cancer cells.
Shen X, Xia Y, Lu H, Zheng P, Wang J, Chen Y, Xu C, Qiu C, Zhang Y, Xiao Z, et al. Biomed Pharmacother. 2024 May; 174:116507. Epub 2024 Apr 1.
Guiding bar motif of thioredoxin reductase 1 modulates enzymatic activity and inhibitor binding by communicating with the co-factor FAD and regulating the flexible C-terminal redox motif. [Redox Biol. 2024]
Guiding bar motif of thioredoxin reductase 1 modulates enzymatic activity and inhibitor binding by communicating with the co-factor FAD and regulating the flexible C-terminal redox motif.
Shi W, Sun S, Liu H, Meng Y, Ren K, Wang G, Liu M, Wu J, Zhang Y, Huang H, et al. Redox Biol. 2024 Apr; 70:103050. Epub 2024 Jan 18.

RefSeq genomic sequence
See the genomic reference sequence for the TXNRD1 gene (NG_029392.1).
RefSeq protein isoforms
See 7 reference sequence protein isoforms for the TXNRD1 gene.

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Q16881 [Domain Mapping of Disease Mut...]
Q16881
Domain Mapping of Disease Mutations
Transcript/Protein Information [PANTHER Classification System]
Transcript/Protein Information
PANTHER Classification System
Reactome [Reactome]
Reactome
reagents [ExactAntigen/Labome]
reagents
ExactAntigen/Labome
reagent reviews [ExactAntigen/Labome]
reagent reviews
ExactAntigen/Labome
Evolutionary Trace of Functional Site [Evolutionary Trace of Functio...]
Evolutionary Trace of Functional Site

RecName: Full=Thioredoxin reductase 1, cytoplasmic; Short=TR; AltName: Full=Gene...
RecName: Full=Thioredoxin reductase 1, cytoplasmic; Short=TR; AltName: Full=Gene associated with retinoic and interferon-induced mortality 12 protein; Short=GRIM-12; Short=Gene associated with retinoic and IFN-induced mortality 12 protein; AltName: Full=KM-102-derived reductase-like factor; AltName: Full=Peroxidase TXNRD1; AltName: Full=Thioredoxin reductase TR1
gi|172046253|sp|Q16881.3|TRXR1_HUMA

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