RecName: Full=Deoxynucleoside triphosphate triphosphohydrolase SAMHD1; - Protein

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SAMHD1 compound heterozygous rare variants associated with moyamoya and mitral valve disease in the absence of other features of Aicardi-Goutières syndrome. [Am J Med Genet A. 2024]
SAMHD1 compound heterozygous rare variants associated with moyamoya and mitral valve disease in the absence of other features of Aicardi-Goutières syndrome.
Karla AR, Pinard A, Boerio ML, Hemelsoet D, Tavernier SJ, De Pauw M, Vereecke E, Fraser S, Bamshad MJ, Guo D, et al. Am J Med Genet A. 2024 Apr; 194(4):e63486. Epub 2023 Dec 1.
Guanine-containing ssDNA and RNA induce dimeric and tetrameric structural forms of SAMHD1. [Nucleic Acids Res. 2023]
Guanine-containing ssDNA and RNA induce dimeric and tetrameric structural forms of SAMHD1.
Orris B, Sung MW, Bhat S, Xu Y, Huynh KW, Han S, Johnson DC, Bosbach B, Shields DJ, Stivers JT. Nucleic Acids Res. 2023 Dec 11; 51(22):12443-12458.
Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction, and cellular dNTP levels. [mBio. 2023]
Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction, and cellular dNTP levels.
Schüssler M, Schott K, Fuchs NV, Oo A, Zahadi M, Rauch P, Kim B, König R. mBio. 2023 Oct 31; 14(5):e0225223. Epub 2023 Oct 6.

RefSeq genomic sequence
See the genomic reference sequence for the SAMHD1 gene (NG_017059.1).
RefSeq protein isoforms
See 3 reference sequence protein isoforms for the SAMHD1 gene.

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Related structures

Q9Y3Z3 [Domain Mapping of Disease Mut...]
Q9Y3Z3
Domain Mapping of Disease Mutations
MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF) [MODBASE, Database of Comparat...]
MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF)
Transcript/Protein Information [PANTHER Classification System]
Transcript/Protein Information
PANTHER Classification System
Reactome [Reactome]
Reactome
reagents [ExactAntigen/Labome]
reagents
ExactAntigen/Labome
reagent reviews [ExactAntigen/Labome]
reagent reviews
ExactAntigen/Labome

RecName: Full=Deoxynucleoside triphosphate triphosphohydrolase SAMHD1; Short=dNT...
RecName: Full=Deoxynucleoside triphosphate triphosphohydrolase SAMHD1; Short=dNTPase; AltName: Full=Dendritic cell-derived IFNG-induced protein; Short=DCIP; AltName: Full=Monocyte protein 5; Short=MOP-5; AltName: Full=SAM domain and HD domain-containing protein 1; Short=hSAMHD1
gi|22257047|sp|Q9Y3Z3.2|SAMH1_HUMAN

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