RecName: Full=Inositol polyphosphate 5-phosphatase OCRL; AltName: Full - Protein

Run BLAST
Find regions of similarity between this sequence and other sequences using BLAST.
Identify Conserved Domains
View conserved domains detected in this protein sequence using CD-search.
Highlight Sequence Features
Opens the Highlight Feature Bar and highlights feature annotations from the FEATURES table of the record. The Highlight Feature Bar can be used to navigate to and highlight other features and provides links to display the highlighted region separately. Links in the FEATURES table will also highlight the corresponding region of the sequence. More...
Find in this Sequence
Finds sub-sequences or patterns in the sequence and highlights the matching regions. The tool works with standard single letter nucleotide or protein codes including ambiguities and can match Prosite patterns in protein sequences. More...

Heterogeneity in Lowe Syndrome: Mutations Affecting the Phosphatase Domain of OCRL1 Differ in Impact on Enzymatic Activity and Severity of Cellular Phenotypes. [Biomolecules. 2023]
Heterogeneity in Lowe Syndrome: Mutations Affecting the Phosphatase Domain of OCRL1 Differ in Impact on Enzymatic Activity and Severity of Cellular Phenotypes.
Lee JJ, Ramadesikan S, Black AF, Christoffer C, Pacheco AFP, Subramanian S, Hanna CB, Barth G, Stauffacher CV, Kihara D, et al. Biomolecules. 2023 Mar 29; 13(4). Epub 2023 Mar 29.
Oculocerebrorenal syndrome of Lowe (OCRL) controls leukemic T-cell survival by preventing excessive PI(4,5)P(2) hydrolysis in the plasma membrane. [J Biol Chem. 2023]
Oculocerebrorenal syndrome of Lowe (OCRL) controls leukemic T-cell survival by preventing excessive PI(4,5)P(2) hydrolysis in the plasma membrane.
Chen H, Lu C, Tan Y, Weber-Boyvat M, Zheng J, Xu M, Xiao J, Liu S, Tang Z, Lai C, et al. J Biol Chem. 2023 Jun; 299(6):104812. Epub 2023 May 11.
Genotype-Phenotype Correlation Reanalysis in 83 Chinese Cases with OCRL Mutations. [Genet Res (Camb). 2022]
Genotype-Phenotype Correlation Reanalysis in 83 Chinese Cases with OCRL Mutations.
Zhang L, Wang S, Mao R, Fu H, Wang J, Shen H, Lu Z, Chen J, Bao Y, Feng C, et al. Genet Res (Camb). 2022; 2022:1473260. Epub 2022 Jul 19.

RefSeq genomic sequence
See the genomic reference sequence for the OCRL gene (NG_008638.1).
RefSeq protein isoforms
See 3 reference sequence protein isoforms for the OCRL gene.

PubMed
PubMed articles cited by protein sequence record
Taxonomy
Taxonomy sequences associated with protein record
BioSystems
BioSystems
CDD Search Results
Display conserved domains within a protein
Conserved Domains (Concise)
Link to a concise list of conserved domains in a protein
Conserved Domains (Full)
Link to conserved domains within a protein
Domain Relatives
Display proteins with similar conserved domain architecture
Full text in PMC
Free full text articles in PMC
Gene
Link to related Genes
Identical Structures
3D structures for identical protein sequences
OMIM
OMIM records associated with protein sequence
Protein (RefSeq)
Protein gi (UniProtKB) to protein gi (refseq)
PubMed (Weighted)
Links to pubmed
Related Structures (List)
List of related structures

Dryad Digital Repository [Dryad Digital Repository]
Dryad Digital Repository
Q01968 [Domain Mapping of Disease Mut...]
Q01968
Domain Mapping of Disease Mutations
Transcript/Protein Information [PANTHER Classification System]
Transcript/Protein Information
PANTHER Classification System
Reactome [Reactome]
Reactome
reagents [ExactAntigen/Labome]
reagents
ExactAntigen/Labome
reagent reviews [ExactAntigen/Labome]
reagent reviews
ExactAntigen/Labome

RecName: Full=Inositol polyphosphate 5-phosphatase OCRL; AltName: Full=Inositol ...
RecName: Full=Inositol polyphosphate 5-phosphatase OCRL; AltName: Full=Inositol polyphosphate 5-phosphatase OCRL-1; Short=OCRL-1; AltName: Full=Lowe oculocerebrorenal syndrome protein; AltName: Full=Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase
gi|67477390|sp|Q01968.3|OCRL_HUMAN

Protein

Your browsing activity is empty.

Activity recording is turned off.

Protein