The stability of HIV-2 Vpx and Vpr proteins is regulated by the presence or absence of zinc-binding sites and poly-proline motifs with distinct roles.
Shimagaki K, Koga R, Fujino H, Ahagon A, Tateishi H, Otsuka M, Yamaguchi Y, Fujita M. J Gen Virol. 2020 Sep; 101(9):997-1007.