sialic acid-binding Ig-like lectin 7 isoform 2 precursor [Homo sapiens - Protein

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The glycoimmune checkpoint receptor Siglec-7 interacts with T-cell ligands and regulates T-cell activation. [J Biol Chem. 2024]
The glycoimmune checkpoint receptor Siglec-7 interacts with T-cell ligands and regulates T-cell activation.
Stewart N, Daly J, Drummond-Guy O, Krishnamoorthy V, Stark JC, Riley NM, Williams KC, Bertozzi CR, Wisnovsky S. J Biol Chem. 2024 Feb; 300(2):105579. Epub 2023 Dec 21.
Histone deacetylation-regulated cell surface Siglec-7 expression promoted megakaryocytic maturation and enhanced platelet-like particle release. [J Thromb Haemost. 2023]
Histone deacetylation-regulated cell surface Siglec-7 expression promoted megakaryocytic maturation and enhanced platelet-like particle release.
Huang YF, Su SC, Chuang HY, Chen HH, Twu YC. J Thromb Haemost. 2023 Feb; 21(2):329-343. Epub 2022 Dec 22.
Siglec-7 represents a glyco-immune checkpoint for non-exhausted effector memory CD8+ T cells with high functional and metabolic capacities. [Front Immunol. 2022]
Siglec-7 represents a glyco-immune checkpoint for non-exhausted effector memory CD8+ T cells with high functional and metabolic capacities.
Haas Q, Markov N, Muerner L, Rubino V, Benjak A, Haubitz M, Baerlocher GM, Ng CKY, Münz C, Riether C, et al. Front Immunol. 2022; 13:996746. Epub 2022 Sep 23.

RefSeq mRNA
See reference mRNA sequence for the SIGLEC7 gene (NM_016543.4).
RefSeq protein isoforms
See 9 reference sequence protein isoforms for the SIGLEC7 gene.

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NP_057627
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OncoMX cancer biomarker resource [OncoMX cancer biomarker resou...]
OncoMX cancer biomarker resource
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