RecName: Full=Neurogenic locus notch homolog protein 2; Short=Notch 2; - Protein

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Pan-cancer tRNA-derived fragment CAT1 coordinates RBPMS to stabilize NOTCH2 mRNA to promote tumorigenesis. [Cell Rep. 2023]
Pan-cancer tRNA-derived fragment CAT1 coordinates RBPMS to stabilize NOTCH2 mRNA to promote tumorigenesis.
Yu M, Yi J, Qiu Q, Yao D, Li J, Yang J, Mi C, Zhou L, Lu B, Lu W, et al. Cell Rep. 2023 Nov 28; 42(11):113408. Epub 2023 Nov 9.
DLBCL-associated NOTCH2 mutations escape ubiquitin-dependent degradation and promote chemoresistance. [Blood. 2023]
DLBCL-associated NOTCH2 mutations escape ubiquitin-dependent degradation and promote chemoresistance.
Zhou N, Choi J, Grothusen G, Kim BJ, Ren D, Cao Z, Liu Y, Li Q, Inamdar A, Beer T, et al. Blood. 2023 Sep 14; 142(11):973-988.
NOTCH2NLC GGC repeat expansion causes retinal pathology with intranuclear inclusions throughout the retina and causes visual impairment. [Acta Neuropathol Commun. 2023]
NOTCH2NLC GGC repeat expansion causes retinal pathology with intranuclear inclusions throughout the retina and causes visual impairment.
Sone J, Ueno S, Akagi A, Miyahara H, Tamai C, Riku Y, Yabata H, Koizumi R, Hattori T, Hirose H, et al. Acta Neuropathol Commun. 2023 May 2; 11(1):71. Epub 2023 May 2.

RefSeq genomic sequence
See the genomic reference sequence for the NOTCH2 gene (NG_008163.2).
RefSeq protein isoforms
See 2 reference sequence protein isoforms for the NOTCH2 gene.

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Q04721 [Domain Mapping of Disease Mut...]
Q04721
Domain Mapping of Disease Mutations
Transcript/Protein Information [PANTHER Classification System]
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PANTHER Classification System
Reactome [Reactome]
Reactome
reagents [ExactAntigen/Labome]
reagents
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ExactAntigen/Labome

RecName: Full=Neurogenic locus notch homolog protein 2; Short=Notch 2; Short=hN2...
RecName: Full=Neurogenic locus notch homolog protein 2; Short=Notch 2; Short=hN2; Contains: RecName: Full=Notch 2 extracellular truncation; Short=N2ECD; Contains: RecName: Full=Notch 2 intracellular domain; Short=N2ICD; Flags: Precursor
gi|143811429|sp|Q04721.3|NOTC2_HUMA

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