ankyrin repeat and LEM domain-containing protein 2 isoform X2 [Homo sa - Protein

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LEM4 confers tamoxifen resistance to breast cancer cells by activating cyclin D-CDK4/6-Rb and ERα pathway. [Nat Commun. 2018]
LEM4 confers tamoxifen resistance to breast cancer cells by activating cyclin D-CDK4/6-Rb and ERα pathway.
Gao A, Sun T, Ma G, Cao J, Hu Q, Chen L, Wang Y, Wang Q, Sun J, Wu R, et al. Nat Commun. 2018 Oct 9; 9(1):4180. Epub 2018 Oct 9.
LEM4/ANKLE-2 deficiency impairs post-mitotic re-localization of BAF, LAP2α and LaminA to the nucleus, causes nuclear envelope instability in telophase and leads to hyperploidy in HeLa cells. [Eur J Cell Biol. 2018]
LEM4/ANKLE-2 deficiency impairs post-mitotic re-localization of BAF, LAP2α and LaminA to the nucleus, causes nuclear envelope instability in telophase and leads to hyperploidy in HeLa cells.
Snyers L, Erhart R, Laffer S, Pusch O, Weipoltshammer K, Schöfer C. Eur J Cell Biol. 2018 Jan; 97(1):63-74. Epub 2017 Dec 11.
ANKLE2-related microcephaly: A variable microcephaly syndrome resembling Zika infection. [Ann Clin Transl Neurol. 2022]
ANKLE2-related microcephaly: A variable microcephaly syndrome resembling Zika infection.
Thomas AX, Link N, Robak LA, Demmler-Harrison G, Pao EC, Squire AE, Michels S, Cohen JS, Comi A, Prontera P, et al. Ann Clin Transl Neurol. 2022 Aug; 9(8):1276-1288. Epub 2022 Jul 24.

RefSeq genomic sequence
See the genomic reference sequence for the ANKLE2 gene (NG_034022.1).
RefSeq mRNA
See reference mRNA sequence for the ANKLE2 gene (XM_006719735.2).

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Protein