This family of glycosyltransferases includes O-linked beta-N-acetylglucosamine (O-GlcNAc) transferase, an enzyme which catalyses the addition of O-GlcNAc to serine and threonine residues [1,2]. In addition to its function as an O-GlcNAc transferase, human OGT, Swiss:O15294, also appears to proteolytically cleave the epigenetic cell-cycle regulator HCF-1 [3]. [1]. 18818698. Structural insights into mechanism and specificity of O-GlcNAc. transferase.. Clarke AJ, Hurtado-Guerrero R, Pathak S, Schuttelkopf AW,. Borodkin V, Shepherd SM, Ibrahim AF, van Aalten DM;. EMBO J. 2008;27:2780-2788.. [2]. 18536723. Structure of an O-GlcNAc transferase homolog provides insight. into intracellular glycosylation.. Martinez-Fleites C, Macauley MS, He Y, Shen DL, Vocadlo DJ,. Davies GJ;. Nat Struct Mol Biol. 2008;15:764-765.. [3]. 21295698. O-GlcNAc Transferase Catalyzes Site-Specific Proteolysis of. HCF-1.. Capotosti F, Guernier S, Lammers F, Waridel P, Cai Y, Jin J,. Conaway JW, Conaway RC, Herr W;. Cell. 2011;144:376-388. (from Pfam)
- Date:
- 2024-08-14