Protein Family Models

Members of this family of nucleic acid binding domains are predominantly found in elongation factor P, where they adopt an OB-fold, with five beta-strands forming a beta-barrel in a Greek-key topology [1]. [1]. 15210970. Crystal structure of elongation factor P from Thermus. thermophilus HB8.. Hanawa-Suetsugu K, Sekine S, Sakai H, Hori-Takemoto C, Terada T,. Unzai S, Tame JR, Kuramitsu S, Shirouzu M, Yokoyama S;. Proc Natl Acad Sci U S A. 2004;101:9595-9600. (from Pfam)

Date:

2024-07-08

Date:

2024-07-08

Date:

2024-07-08

elongation factor P (EF-P) is an essential protein that stimulates ribosomal peptidyltransferase activity

Date:

2023-03-08

Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA

Date:

2020-10-26

function: involved in peptide bond synthesis. stimulate efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (by similarity). The trusted cutoff of this model is set high enough to exclude members of TIGR02178, an EFP-like protein of certain Gammaproteobacteria.

Gene:

efp

Date:

2021-04-27