Protein Family Models for Protein (Select 1914436258) - Protein Family Models

Select item 4273711.

Nicotinate phosphoribosyltransferase C-terminal domain

This domain is found at the C-terminus of some Nicotinate phosphoribosyltransferase enzymes. The function of this domain is uncertain. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF037014.5
Method:: HMM

Select item 4263802.

Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain

Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyses the first reaction in the NAD salvage synthesis. This is the N-terminal domain of the enzyme. [1]. 16154095. The structure of a eukaryotic nicotinic acid. phosphoribosyltransferase reveals structural heterogeneity among. type II PRTases.. Chappie JS, Canaves JM, Han GW, Rife CL, Xu Q, Stevens RC;. Structure. 2005;13:1385-1396. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF036998.5
Method:: HMM

Select item 4139503.

Nicotinate phosphoribosyltransferase (NAPRTase) family

Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyses the first reaction in the NAD salvage synthesis. This family also includes Pre-B cell enhancing factor that is a cytokine Swiss:P43490. This family is related to Quinolinate phosphoribosyltransferase Pfam:PF01729. [1]. 10825532. Salvage pathway for NAD biosynthesis in Brevibacterium. ammoniagenes: regulatory properties of triphosphate-dependent. nicotinate phosphoribosyltransferase.. Dulyaninova NG, Podlepa EM, Toulokhonova1 LV, Bykhovsky VY;. Biochim Biophys Acta 2000;1478:211-220. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF016021.5
Method:: HMM

Select item 4077324.

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Select item 4050755.

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Select item 3913146.

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Select item 3612988.

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Select item 33020110.

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Select item 33018911.

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Select item 31939112.

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Select item 17033513.

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Select item 17033114.

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Select item 16790715.

nicotinate phosphoribosyltransferase

GO Terms:

Molecular Function:: nicotinate-nucleotide diphosphorylase (carboxylating) activity (GO:0004514)

Biological Process:: NAD biosynthetic process (GO:0009435)

Date:: 2021-10-28

Family Accession:: NF006696.0
Method:: HMM

Select item 14147916.

nicotinate phosphoribosyltransferase

A deep split separates two related families of proteins, one of which includes experimentally characterized examples of nicotinate phosphoribosyltransferase, an the first enzyme of NAD salvage biosynthesis. This HMM represents the other family. Members have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. One argument suggesting that this family represents the same enzyme is that no species has a member of both families. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria. NAD and NADP are ubiquitous in life. Most members of this family are Gram-positive bacteria. An additional set of mutually closely related archaeal sequences score between the trusted and noise cutoffs.

Gene:: pncB

GO Terms:

Molecular Function:: nicotinate phosphoribosyltransferase activity (GO:0004516)

Biological Process:: NAD biosynthetic process (GO:0009435)

Date:: 2024-06-11

Family Accession:: TIGR01513.1
Method:: HMM

Select item 2937317.

nicotinate phosphoribosyltransferase

Catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate

Date:: 2020-10-26

Family Accession:: NF009131.0
Method:: HMM

Select item 1027218.

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