Protein Family Models

Date:

2024-07-13

Filamentous hemagglutinin (FHA), the major 230-kDa adhesin of the whooping cough agent Bordetella pertussis, is one of the most efficiently secreted proteins in Gram-negative bacteria. FHA is secreted by means of the two-partner secretion (TPS) pathway. A TPS system is composed of two separate proteins, with TpsA the secreted protein and TpsB its associated specific outer-membrane transporter. All TPS-secreted proteins contain a distinctive N-proximal module essential for secretion, the TPS domain. The TPS domain folds into a beta-helix. This domain is found in a wide variety of secreted proteins from bacterial pathogens. [1]. 15079085. The crystal structure of filamentous hemagglutinin secretion. domain and its implications for the two-partner secretion. pathway.. Clantin B, Hodak H, Willery E, Locht C, Jacob-Dubuisson F,. Villeret V;. Proc Natl Acad Sci U S A. 2004;101:6194-6199. (from Pfam)

Date:

2024-07-10

This family represents a conserved region found in many bacterial porlymorphic toxins which is located before the C-terminal toxin modules [1][2]. [1]. 21306995. A novel immunity system for bacterial nucleic acid degrading. toxins and its recruitment in various eukaryotic and DNA viral. systems.. Zhang D, Iyer LM, Aravind L;. Nucleic Acids Res. 2011;39:4532-4552.. [2]. 21085179. A widespread family of polymorphic contact-dependent toxin. delivery systems in bacteria.. Aoki SK, Diner EJ, de Roodenbeke CT, Burgess BR, Poole SJ,. Braaten BA, Jones AM, Webb JS, Hayes CS, Cotter PA, Low DA;. Nature. 2010;468:439-442. (from Pfam)

Date:

2024-07-11

CdiA proteins are the effector partner of a contact-dependent growth inhibition (CDI) systems. Transport depends on CdiB proteins in a two-partner secretion system, a subclass of type V secrection system.

Gene:

cdiA

Date:

2020-08-25

protein containing domains TPS, FhaB, Fil_haemagg_2, and PT-VENN

Date:

2017-03-02

This HMM represents a conserved domain found near the N-terminus of a number of large, repetitive bacterial proteins, including many proteins of over 2500 amino acids. Members generally have a signal sequence, then an intervening region, then the region described by this HMM. Following this region, proteins typically have regions rich in repeats but may show no homology between the repeats of one member and the repeats of another. A number of the members of this family have been designated adhesins, filamentous haemagglutinins, heme/hemopexin-binding protein, etc.

Date:

2019-09-10

This HMM represents two copies of a 20-residue repeat found in Bordetella pertussis filamentous hemagglutinin family of adhesins. This family includes extremely long proteins from a number of plant and animal pathogens.

Date:

2021-08-12