Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
serine hydrolase
This is the catalytic domain of class A beta-lactamases [1]. It is closely related to Beta-lactamase, Pfam:PF00144, the serine beta-lactamase-like superfamily, which contains the distantly related Pfam:PF00905 and PF00768 D-alanyl-D-alanine carboxypeptidase. [1]. 19100272. Structure of PBP-A from Thermosynechococcus elongatus, a. penicillin-binding protein closely related to class A. beta-lactamases.. Urbach C, Evrard C, Pudzaitis V, Fastrez J, Soumillion P,. Declercq JP;. J Mol Biol. 2009;386:109-120. (from Pfam)
This model finds serine hydrolases of many sorts, including class C beta-lactamases. Despite the name given by Pfam as a short-hand for this HMM, members proteins should be assumed to be something other than a beta-lactamase if RefSeq or PGAP uses this HMM for naming. True beta-lactamases are named by more specific HMMs.
class A beta-lactamase family protein
class A beta-lactamase family protein hydrolyzes the beta-lactam bond in susceptible beta-lactam antibiotics such as penicillins and cephalosporins
TEM family class A beta-lactamase
Members of this family are class A beta-lactamases from the narrowly defined family TEM. All full length beta-lactamases scoring above the trusted cutoff are proper members of the TEM family, and no true TEM is missed.
class A beta-lactamase
Filter your results:
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on