Protein Family Models

PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of different toxins, such as MazF, Kid, PemK, ChpA, ChpB and ChpAK. [1]. 8226627. chpA and chpB, Escherichia coli chromosomal homologs of the pem. locus responsible for stable maintenance of plasmid R100.. Masuda Y, Miyakawa K, Nishimura Y, Ohtsubo E;. J Bacteriol 1993;175:6850-6856.. [2]. 22060041. Toxin-antitoxin systems in bacteria and archaea.. Yamaguchi Y, Park JH, Inouye M;. Annu Rev Genet. 2011;45:61-79.. [3]. 21927020. Regulation of growth and death in Escherichia coli by. toxin-antitoxin systems.. Yamaguchi Y, Inouye M;. Nat Rev Microbiol. 2011;9:779-790. (from Pfam)

Date:

2024-07-09