Protein Family Models for Protein (Select 446661859) - Protein Family Models

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Items: 4

Select item 4213931.

fibrinogen-binding protein

This domain family is found in bacteria, and is approximately 70 amino acids in length. There is a conserved VLK sequence motif. It is the C terminal domain of bacterial extracellular fibrinogen binding protein. It contains a helical motif involved in complement regulation. This motif binds to complement and changes its conformation to a form which cannot activate downstream components of the complement cascade. [1]. 17351618. A structural basis for complement inhibition by Staphylococcus. aureus.. Hammel M, Sfyroera G, Ricklin D, Magotti P, Lambris JD,. Geisbrecht BV;. Nat Immunol. 2007;8:430-437. (from Pfam)

GO Terms:

Molecular Function:: complement binding (GO:0001848)

Cellular Component:: extracellular space (GO:0005615)

Date:: 2024-08-14

Family Accession:: NF023620.5
Method:: HMM

Select item 3985992.

new record, indexing in progress

Family Accession:

Select item 3628383.

new record, indexing in progress

Family Accession:

Select item 1069754.

fibrinogen-binding protein

fibrinogen-binding protein plays an important role in virulence and interacts with the alpha chain of fibrinogen and its derivative fibrin, which enhances a non-functional interaction between fibrinogen and platelets and is responsible for repression of fibrinogen-dependent platelet aggregation