Protein Family Models for Protein (Select 490173398) - Protein Family Models

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Items: 4

Select item 4183441.

prepilin-type N-terminal cleavage/methylation domain-containing protein

This short motif directs methylation of the conserved phenylalanine residue. It is most often found at the N-terminus of pilins and other proteins involved in secretion, see Pfam:PF00114, Pfam:PF05946, Pfam:PF02501 and Pfam:PF07596. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF019575.5
Method:: HMM

Select item 3951742.

new record, indexing in progress

Family Accession:

Select item 3568533.

new record, indexing in progress

Family Accession:

Select item 506234.

prepilin-type N-terminal cleavage/methylation domain-containing protein

This model describes many but not all examples of the N-terminal region of bacterial proteins that resemble type IV pilins at their N-terminus, with a cleavage site G^FxxxE followed by a hydrophobic stretch. The new N-terminal residue, usually Phe, is methylated. Separate domains of the prepilin peptidase appear responsible for cleavage and methylation. Proteins with this N-terminal region include type IV pilins and other components of pilus biogenesis, competence proteins, and type II secretion proteins. Typically several proteins in a single operon have this N-terminal domain. The N-terminal cleavage and methylation site is described by PROSITE motif PS00409 as [KRHEQSTAG]-G-[FYLIVM]-[ST]-[LT]-[LIVP]-E-[LIVMFWSTAG](14).