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conjugal transfer protein TraG N-terminal domain-containing protein
The bacterial sequences found in this family are similar to the N-terminal region of the TraG protein (Swiss:P33790). This is a membrane-spanning protein, with three predicted transmembrane segments and two periplasmic regions [1]. TraG protein is known to be essential for DNA transfer in the process of conjugation, with the N-terminal portion being required for F pilus assembly [1,2]. The protein is thought to interact with the periplasmic domain of TraN (Swiss:P24082) to stabilise mating-cell interactions [2]. [1]. 1348105. Characterization of the F plasmid bifunctional conjugation gene,. traG.. Firth N, Skurray R;. Mol Gen Genet 1992;232:145-153.. [2]. 7915817. Analysis of the sequence and gene products of the transfer. region of the F sex factor.. Frost LS, Ippen-Ihler K, Skurray RA;. Microbiol Rev 1994;58:162-210. (from Pfam)
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