Protein Family Models

A member of the RnfH family of the ubiquitin superfamily. Members of this family strongly co-occur in two distinct gene neighborhood contexts. In one it is associated with a START domain protein, a membrane protein SmpA and the transfer mRNA binding protein SmpB. This association suggests a possible role in the SmpB-tmRNA-based tagging and degadation system of bacteria, which is interesting given that other members of the ubiquitin system are analogously involved in protein-tagging and degradation across eukaryotes and various prokaryotes. The second context in which the RnfH genes are present is in a membrane associated complex involved in transporting electrons for various reductive reactions such as nitrogen fixation [1]. [1]. 16859499. The prokaryotic antecedents of the ubiquitin-signaling system. and the early evolution of ubiquitin-like beta-grasp domains.. Iyer LM, Burroughs AM, Aravind L;. Genome Biol. 2006;7:R60. (from Pfam)

Date:

2024-08-14

ThiS (thiaminS) is a 66 aa protein involved in sulphur transfer Swiss:O32583. ThiS is coded in the thiCEFSGH operon in E. coli. This family of proteins have two conserved Glycines at the COOH terminus. Thiocarboxylate is formed at the last G in the activation process. Sulphur is transferred from ThiI to ThiS in a reaction catalysed by IscS [1]. MoaD, Swiss:P30748 a protein involved sulphur transfer in molybdopterin synthesis, is about the same length and shows limited sequence similarity to ThiS. Both have the conserved GG at the COOH end. [1]. 10781607. The iscS gene in Escherichia coli is required for the. biosynthesis of 4-thiouridine, thiamin, and NAD.. Lauhon CT, Kambampati R;. J Biol Chem 2000;275:20096-20103. (from Pfam)

Date:

2024-08-14

Date:

2020-10-26

RnfH family protein, a member of the ubiquitin superfamily, is involved in transporting electrons for various reductive reactions such as nitrogen fixation and may also play a role in the SmpB-tmRNA-based tagging and degradation system of bacteria

Date:

2016-08-01