Protein Family Models

This family is closely related to the Pfam:PF09084 family. (from Pfam)

Date:

2024-08-14

This is a family of periplasmic proteins which are part of the transport system for alkylphosphonate uptake. (from Pfam)

Date:

2024-08-14

This family contains the NMT1 and THI5 proteins. These proteins are proposed to be required for the biosynthesis of the pyrimidine moiety of thiamine [1][2][3]. They are regulated by thiamine [2]. The protein adopts a fold related to the periplasmic binding protein (PBP) family. Both pyridoxal-5'-phosphate (PLP) and an iron atom are bound to the protein suggesting numerous residues of the active site necessary for HMP-P biosynthesis. The yeast protein is a dimer and, although exceptionally using PLP as a substrate, has notable similarities with enzymes dependent on this molecule as a cofactor [4]. [1]. 12271461. Functional analysis of yeast gene families involved in. metabolism of vitamins B1 and B6.. Rodriguez-Navarro S, Llorente B, Rodriguez-Manzaneque MT, Ramne. A, Uber G, Marchesan D, Dujon B, Herrero E, Sunnerhagen P,. Perez-Ortin JE;. Yeast. 2002;19:1261-1276.. [2]. 2358444. nmt1 of fission yeast. A highly transcribed gene completely. repressed by thiamine.. Maundrell K;. J Biol Chem. 1990;265:10857-10864.. [3]. 12777485. The THI5 gene family of Saccharomyces cerevisiae: distribution. of homologues among the hemiascomycetes and functional. redundancy in the aerobic biosynthesis of thiamin from. pyridoxine.. Wightman R, Meacock PA;. Microbiology. 2003;149:1447-1460.. [4]. 23048037. The last piece in the vitamin B1 biosynthesis puzzle: structural. and functional insight into yeast. 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P). synthase.. Coquille S, Roux C, Fitzpatrick TB, Thore S;. J Biol Chem. 2012;287:42333-42343. (from Pfam)

Date:

2024-08-14

PBP2_SsuA_like_1 domain-containing protein

Date:

2017-03-02

Members of this family are substrate-binding periplasmic proteins of ABC transporters. This subfamily includes SsuA, a member of a transporter operon needed to obtain sulfur from aliphatic sulfonates. Related proteins outside the scope of this HMM include taurine (NH2-CH2-CH2-S03H) binding proteins, the probable sulfate ester binding protein AtsR, and the probable aromatic sulfonate binding protein AsfC. All these families make sulfur available when Cys and sulfate levels are low. Please note that phylogenetic analysis by neighbor-joining suggests that a number of sequences belonging to this family have been excluded because of scoring lower than taurine-binding proteins.

Date:

2024-06-14