Protein Family Models

Date:

2023-12-12

This entry represents the N-terminal domain of terminase large subunits found in a variety of the Caudovirales and prophage regions of bacterial genomes. It includes the terminase large subunit of Bacteriophage T4 (terminase gene 17, Gp17) [1,3]. Homologues are also found in Gene Transfer Agents (GTA) [2], including ORFg2 (RCAP_rcc01683) of the GTA of Rhodobacter capsulatus (Rhodopseudomonas capsulata) [see Fig.1, in 4]. [1]. 12235385. Sequence analysis of bacteriophage T4 DNA packaging/terminase. genes 16 and 17 reveals a common ATPase center in the large. subunit of viral terminases.. Mitchell MS, Matsuzaki S, Imai S, Rao VB;. Nucleic Acids Res. 2002;30:4009-4021.. [2]. 11382219. The gene transfer agent of Rhodobacter capsulatus and. "constitutive transduction" in prokaryotes.. Lang AS, Beatty JT;. Arch Microbiol. 2001;175:241-249.. [3]. 12466275. Isolation and characterization of T4 bacteriophage gp17. terminase, a large subunit multimer with enhanced ATPase. activity.. Baumann RG, Black LW;. J Biol Chem. 2003;278:4618-4627.. [4]. 12399927. Evolutionary implications of phylogenetic analyses of the gene. transfer agent (GTA) of Rhodobacter capsulatus.. Lang AS, Taylor TA, Beatty JT;. J Mol Evol. 2002;55:534-543. (from Pfam)

Date:

2024-04-03

terminase large subunit acts as an ATP driven molecular motor necessary for viral DNA translocation into empty capsids and as an endonuclease that cuts the viral genome to initiate and to end a packaging reaction

Date:

2020-07-15