This bacteriophage protein forms a gateway that enables DNA passage during packaging and ejection of the phage genome. It also forms the junction between the phage head (capsid) and the tail proteins. During SPP1 morphogenesis, the portal protein, Gp6, participates in the procapsid assembly reaction [1,2]. In the mature SPP1 virion, Gp6 exists as a dodecamer, while recombinant SPP1 Gp6 has been shown to form 13-subunit assemblies [1,3]. This protein is common to Siphoviridae (phages with long non-contractile tails) and Myoviridae (phages with contractile tails). It is also found in a number of bacterial species. This family also includes the old Pfam family Phage_min_cap (PF:PF05126). RC Paper describing PDB structure 2jes [1]. 11501993. Structural organisation of the head-to-tail interface of a. bacterial virus.. Lurz R, Orlova EV, Gunther D, Dube P, Droge A, Weise F, van Heel. M, Tavares P;. J Mol Biol 2001;310:1027-1037.. [2]. 25991862. Structural rearrangements in the phage head-to-tail interface. during assembly and infection.. Chaban Y, Lurz R, Brasiles S, Cornilleau C, Karreman M,. Zinn-Justin S, Tavares P, Orlova EV;. Proc Natl Acad Sci U S A. 2015;112:7009-7014.. [3]. 17363899. Structural framework for DNA translocation via the viral portal. protein.. Lebedev AA, Krause MH, Isidro AL, Vagin AA, Orlova EV, Turner J,. Dodson EJ, Tavares P, Antson AA;. EMBO J. 2007;26:1984-1994. (from Pfam)
- Date:
- 2024-07-08