Protein Family Models

This family includes multiple HEAT repeats. (from Pfam)

Date:

2024-08-14

This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation [1]. This family is closely related to Pfam:PF00931. [1]. 10782090. The NACHT family - a new group of predicted NTPases implicated. in apoptosis and MHC transcription activation.. Koonin EV, Aravind L;. Trends Biochem Sci 2000;25:223-224. (from Pfam)

Date:

2024-08-14

The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see Pfam:PF00514). [1]. 7550332. HEAT repeats in the Huntington's disease protein.. Andrade MA, Bork P;. Nat Genet 1995;11:115-116.. [2]. 9989501. The structure of the protein phosphatase 2A PR65/A subunit. reveals the conformation of its 15 tandemly repeated HEAT. motifs.. Groves MR, Hanlon N, Turowski P, Hemmings BA, Barford D;. Cell 1999;96:99-110. (from Pfam)

Date:

2024-08-14

This family contains a short bi-helical repeat that is related to Pfam:PF02985. Cyanobacteria and red algae harvest light energy using macromolecular complexes known as phycobilisomes (PBS), peripherally attached to the photosynthetic membrane. The major components of PBS are the phycobiliproteins. These heterodimeric proteins are covalently attached to phycobilins: open-chain tetrapyrrole chromophores, which function as the photosynthetic light-harvesting pigments. Phycobiliproteins differ in sequence and in the nature and number of attached phycobilins to each of their subunits. This family includes the lyase enzymes that specifically attach particular phycobilins to apophycobiliprotein subunits. The most comprehensively studied of these is the CpcE/F lyase Swiss:P31967 Swiss:P31968, which attaches phycocyanobilin (PCB) to the alpha subunit of apophycocyanin [1]. Similarly, MpeU/V attaches phycoerythrobilin to phycoerythrin II, while CpeY/Z is thought to be involved in phycoerythrobilin (PEB) attachment to phycoerythrin (PE) I (PEs I and II differ in sequence and in the number of attached molecules of PEB: PE I has five, PE II has six) [2]. All the reactions of the above lyases involve an apoprotein cysteine SH addition to a terminal delta 3,3'-double bond. Such a reaction is not possible in the case of phycoviolobilin (PVB), the phycobilin of alpha-phycoerythrocyanin (alpha-PEC). It is thought that in this case, PCB, not PVB, is first added to apo-alpha-PEC, and is then isomerised to PVB. The addition reaction has been shown to occur in the presence of either of the components of alpha-PEC-PVB lyase PecE or PecF (or bo. TRUNCATED at 1650 bytes (from Pfam)

Date:

2024-08-14