V - Defense mechanisms
Stats
COG definitions |
Organims | Proteins | Median Protein Length |
Genes |
---|---|---|---|---|
175 | 1,304 | 115,502 | 320.0 | 153 |
Organism | Protein | COG | Cat | Annotation |
---|---|---|---|---|
1153 | 3675 | COG0251 | V | Enamine deaminase RidA/Endoribonuclease Rid7C, YjgF/YER057c/UK114 family |
861 | 1878 | COG0286 | V | Type I restriction-modification system, DNA methylase subunit |
636 | 863 | COG0386 | V I | Thioredoxin/glutathione peroxidase BtuE, reduces lipid peroxides |
1167 | 3580 | COG0388 | V | Nitrilase/amidase YafV/Nit2, hydrolyzes deaminated glutathione |
982 | 1481 | COG0450 | V | Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin) |
1140 | 3344 | COG0494 | V | 8-oxo-dGTP pyrophosphatase MutT and related house-cleaning NTP pyrophosphohydrolases, NUDIX family |
1052 | 3254 | COG0534 | V | Na+-driven multidrug efflux pump, DinF/NorM/MATE family |
935 | 3370 | COG0577 | V | ABC-type antimicrobial peptide transport system, permease component |
587 | 875 | COG0610 | V | Type I site-specific restriction-modification system, R (restriction) subunit and related helicases ... |
582 | 854 | COG0627 | V | S-formylglutathione hydrolase FrmB |
920 | 1861 | COG0693 | V | Protein/nucleotide deglycase, PfpI/YajL/DJ-1 family (repair of methylglyoxal-glycated proteins and nucleic acids) |
713 | 1385 | COG0732 | V | Restriction endonuclease S subunit |
782 | 1524 | COG0737 | V F | 2',3'-cyclic-nucleotide 2'-phosphodiesterase/5'- or 3'-nucleotidase, 5'-nucleotidase family |
951 | 986 | COG0756 | V F | dUTP pyrophosphatase (dUTPase) |
760 | 1035 | COG0783 | V P | DNA-binding ferritin-like protein (oxidative damage protectant) |
938 | 4947 | COG0841 | V | Multidrug efflux pump subunit AcrB |
1085 | 3770 | COG0842 | V | ABC-type multidrug transport system, permease component |
975 | 6816 | COG0845 | V M | Multidrug efflux pump subunit AcrA (membrane-fusion protein) |
112 | 128 | COG1002 | V | Type II restriction/modification system, endonuclease and methylase domains |
60 | 60 | COG1059 | L V | Thermostable 8-oxoguanine DNA glycosylase |
1213 | 8423 | COG1131 | V | ABC-type multidrug transport system, ATPase component |
1210 | 7067 | COG1132 | V | ABC-type multidrug transport system, ATPase and permease component |
75 | 75 | COG1133 | V | Peptide antibiotic transporter SbmA/BacA, ABC-type permease family |
496 | 672 | COG1203 | V | CRISPR-Cas type I system-associated endonuclease/helicase Cas3 |
305 | 347 | COG1275 | V | Tellurite resistance protein TehA and related permeases |
76 | 79 | COG1332 | V | CRISPR-Cas system type III CSM-effector complex subunit Csm5, RAMP superfamily Cas7 group |
125 | 154 | COG1336 | V | CRISPR-Cas system type III CMR-effector complex subunit Cmr4, RAMP superfamily Cas7 group |
149 | 324 | COG1337 | V | CRISPR-Cas system type III CSM-effector complex subunit Csm3, RAMP superfamily Cas7 group |
487 | 736 | COG1343 | V | CRISPR/Cas system-associated endoribonuclease Cas2 |
189 | 238 | COG1353 | V | CRISPR/Cas system-associated protein Cas10, large subunit of type III CRISPR-Cas systems, contains HD superfamily nuclease domain |
81 | 87 | COG1367 | V | CRISPR-Cas system type III CMR-effector complex subunit Cmr1, RAMP superfamily Cas7 group |
257 | 291 | COG1401 | V | 5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB |
719 | 1475 | COG1403 | V | 5-methylcytosine-specific restriction endonuclease McrA |
49 | 52 | COG1421 | V | CRISPR-Cas system type III CSM-effector complex small subunit Csm2 |
35 | 38 | COG1431 | J V | PIWI domain, catalyzes dsRNA-guided hydrolysis of ssRNA, involved in RNA silencing, RNA metabolism and antiviral defense |
386 | 547 | COG1468 | V | CRISPR/Cas system-associated exonuclease Cas4, RecB family |
390 | 538 | COG1479 | V | DNAse/DNA nickase specific for phosphorothioated or glycosylated phage DNA, GmrSD/DndB/SspE family, contains DUF262 and HNH nuclease domains |
509 | 1363 | COG1487 | V | Ribonuclease/mRNA interferase VapC, contains PIN domain |
28 | 37 | COG1517 | V | CRISPR/Cas system-associated protein Csx1, contains CARF domain |
582 | 897 | COG1518 | V | CRISPR-Cas system-associated integrase Cas1 |
867 | 4581 | COG1566 | V | Multidrug resistance efflux pump EmrA |
76 | 79 | COG1567 | V | CRISPR-Cas system type III CSM-effector complex subunit Csm4, RAMP superfamily Cas5 group |
143 | 156 | COG1578 | V | House-cleaning carbohydrate phosphatase, DUF89 family |
172 | 230 | COG1583 | V | CRISPR/Cas system endoribonuclease Cas6, RAMP superfamily |
371 | 1042 | COG1598 | V | Antitoxin component HicB of the HicAB toxin-antitoxin system |
109 | 122 | COG1604 | V | CRISPR/Cas system CMR subunit Cmr6, Cas7 group, RAMP superfamily |
132 | 134 | COG1659 | V | Bacteriocin, linocin/CFP29 family |
831 | 4078 | COG1680 | V | CubicO group peptidase, beta-lactamase class C family |
106 | 116 | COG1688 | V | CRISPR/Cas system-associated protein Cas5, RAMP superfamily |
463 | 557 | COG1694 | V | NTP pyrophosphatase, house-cleaning of non-canonical NTPs |
43 | 45 | COG1700 | V | Predicted anti-virus defense system component AQ645, contains DUF2357 and PD-(D/E)xK nuclease domains |
289 | 350 | COG1715 | V | Restriction endonuclease Mrr |
39 | 64 | COG1753 | V | Predicted antitoxin, CopG family |
612 | 1184 | COG1764 | V | Organic hydroperoxide reductase OsmC/OhrA |
74 | 77 | COG1769 | V | CRISPR-Cas system type III CMR-effector complex subunit Cmr3, RAMP superfamily Cas5 group |
99 | 129 | COG1787 | V | Endonuclease, HJR/Mrr/RecB family |
249 | 564 | COG1848 | V | VapC family ribonuclease, toxin component of the VapBC toxin-antitoxin module, contains PIN domain |
102 | 115 | COG1857 | V | CRISPR-Cas system type I effector complex subunit Cas7, RAMP superfamily |
111 | 147 | COG1895 | V | HEPN domain protein, predicted toxin of MNT-HEPN system |
370 | 397 | COG1912 | V H | Stereoselective (R,S)-S-adenosylmethionine hydrolase (adenosine-forming) |
522 | 605 | COG1956 | V T | GAF domain-containing protein, putative methionine-R-sulfoxide reductase |
197 | 202 | COG1986 | V F | Non-canonical (house-cleaning) NTP pyrophosphatase, all-alpha NTP-PPase family |
427 | 840 | COG2002 | K V | Bifunctional DNA-binding transcriptional regulator of stationary/sporulation/toxin gene expression and antitoxin component of the YhaV-PrlF toxin-antitoxin module |
428 | 769 | COG2026 | V | mRNA-degrading endonuclease RelE, toxin component of the RelBE toxin-antitoxin system |
722 | 1454 | COG2076 | V | Multidrug transporter EmrE and related cation transporters |
527 | 2971 | COG2124 | V Q | Cytochrome P450 |
354 | 583 | COG2161 | V | Antitoxin component YafN of the YafNO toxin-antitoxin module, PHD/YefM family |
141 | 390 | COG2250 | V | HEPN domain protein, predicted toxin of MNT-HEPN system |
221 | 293 | COG2253 | V | Predicted nucleotidyltransferase component of viral defense system |
25 | 31 | COG2254 | V | CRISPR/Cas system-associated endonuclease Cas3-HD |
580 | 745 | COG2258 | V F | N-hydroxylaminopurine reductase YiiM, contains MOSC domain |
626 | 1426 | COG2274 | V | ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain |
232 | 305 | COG2336 | V | Antitoxin component MazE of the MazEF toxin-antitoxin module |
498 | 843 | COG2337 | V | mRNA-degrading endonuclease MazF, toxin component of the MazEF toxin-antitoxin module |
268 | 474 | COG2361 | V | HEPN domain protein, predicted toxin of MNT-HEPN system |
479 | 804 | COG2367 | V | Beta-lactamase class A |
187 | 626 | COG2442 | V | Predicted antitoxin component of a toxin-antitoxin system, DUF433 family |
134 | 149 | COG2602 | V | Beta-lactamase class D |
257 | 389 | COG2720 | V | Vancomycin resistance protein YoaR (function unknown), contains peptidoglycan-binding and VanW domains |
131 | 149 | COG2746 | V | Aminoglycoside N3'-acetyltransferase |
50 | 54 | COG2810 | V | Predicted type IV restriction endonuclease |
209 | 544 | COG2849 | V | Antitoxin component YwqK of the YwqJK toxin-antitoxin module |
312 | 346 | COG2914 | V | Putative antitoxin component PasI (RatB) of the RatAB toxin-antitoxin module, ubiquitin-RnfH superfamily |
201 | 400 | COG2929 | V | Ribonuclease BrnT, toxin component of the BrnT-BrnA toxin-antitoxin system |
119 | 128 | COG3015 | V M | Uncharacterized lipoprotein NlpE involved in copper resistance |
178 | 245 | COG3041 | J V | mRNA-degrading endonuclease YafQ (mRNA interferase), toxin component of the YafQ-DinJ toxin-antitoxin module |
80 | 97 | COG3059 | V | Reactive chlorine resistance protein RclC/YkgB, DUF417 family |
220 | 374 | COG3077 | V | Antitoxin component of the RelBE or YafQ-DinJ toxin-antitoxin module |
432 | 752 | COG3093 | V | Plasmid maintenance system antidote protein VapI/HigA, contains XRE-type HTH domain |
132 | 133 | COG3155 | V | Glyoxalase ElbB, DJ-1 superfamily |
150 | 158 | COG3183 | V | Predicted restriction endonuclease, HNH family |
423 | 475 | COG3217 | V F | N-hydroxylaminopurine reductase subunit YcbX, contains MOSC domain |
164 | 197 | COG3236 | V H | N-glycosidase YbiA/RibX (riboflavin biosynthesis, damage control), NADAR superfamily |
22 | 24 | COG3309 | V | Virulence-associated protein VapD, endoribonuclease |
60 | 62 | COG3337 | V | CRISPR-Cas system type III CMR-effector complex small subunit Cmr5 |
391 | 1452 | COG3415 | V | CRISPR-associated protein Csa3, CARF domain |
27 | 30 | COG3421 | V | Type III restriction endonuclease |
256 | 303 | COG3440 | V | Predicted restriction endonuclease |
465 | 866 | COG3467 | V | Nitroimidazole reductase NimA or a related FMN-containing flavoprotein, pyridoxamine 5'-phosphate oxidase superfamily |
79 | 91 | COG3510 | V | Cephalosporin hydroxylase |
104 | 115 | COG3513 | V | CRISPR-Cas system type-II protein Cas9 |
161 | 259 | COG3514 | V | Antitoxin component of the BrnT-BrnA toxin-antitoxin system |
265 | 406 | COG3549 | V | Plasmid maintenance system killer protein |
135 | 163 | COG3570 | V | Streptomycin 6-kinase |
52 | 64 | COG3582 | V | CDC48-associated ubiquitin-like protein CUZ1, contains AN1-type Zn-finger (protection from As/Sb toxicity) |
170 | 189 | COG3587 | V | Restriction endonuclease, type III RM system |
390 | 416 | COG3634 | V | Alkyl hydroperoxide reductase subunit AhpF |
214 | 238 | COG3649 | V | CRISPR-Cas system type I effector complex subunit Cas7, RAMP superfamily |
171 | 233 | COG3657 | V | Putative component of the toxin-antitoxin plasmid stabilization module |
115 | 115 | COG3725 | V | Membrane protein AmpE required for beta-lactamase induction |
82 | 135 | COG3742 | V | VapC family ribonuclease, contains PIN domain |
198 | 385 | COG3744 | V | PIN domain nuclease, a component of toxin-antitoxin system (PIN domain) |
226 | 253 | COG3853 | V | Uncharacterized conserved protein YaaN involved in tellurite resistance |
42 | 49 | COG3896 | V | Chloramphenicol 3-O-phosphotransferase |
49 | 57 | COG4006 | V | CRISPR-Cas system-associated protein Csm6, contains CARF domain |
18 | 18 | COG4088 | J V | tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) |
305 | 376 | COG4096 | V | Type I site-specific restriction endonuclease, part of a restriction-modification system |
68 | 76 | COG4110 | V | Tellurium resistance protein TerA/TerD |
214 | 373 | COG4113 | V | RNA interferase (RNase) VapC, contains PIN domain |
269 | 377 | COG4115 | V | Toxin component of the Txe-Axe toxin-antitoxin module, Txe/YoeB family |
326 | 700 | COG4118 | V | Antitoxin component of toxin-antitoxin stability system, DNA-binding transcriptional repressor |
91 | 91 | COG4167 | V | ABC-type antimicrobial peptide export system, ATPase component SapF |
90 | 91 | COG4168 | V | ABC-type antimicrobial peptide export system, permease component SapB |
97 | 98 | COG4170 | V | ABC-type antimicrobial peptide export system, ATPase component SapD |
98 | 100 | COG4171 | V | ABC-type antimicrobial peptide export system, permease component SapC |
69 | 103 | COG4200 | V | Predicted lantabiotic-exporting membrane pepmease, EfiE/EfiG/ABC2 family |
177 | 263 | COG4257 | V | Streptogramin lyase |
194 | 211 | COG4268 | V | 5-methylcytosine-specific restriction endonuclease McrBC, regulatory subunit McrC |
34 | 42 | COG4343 | V | CRISPR/Cas system-associated exonuclease Cas4, RecB family |
47 | 61 | COG4374 | V | PIN domain nuclease, a component of toxin-antitoxin system (PIN domain) |
109 | 194 | COG4403 | V | Lantibiotic modifying enzyme |
128 | 130 | COG4452 | V | Inner membrane protein CreD involved in colicin E2 resistance |
128 | 165 | COG4461 | V | Lysozyme inhibitor LprI |
219 | 315 | COG4679 | V X | Phage-related protein gp49, toxin component of the Tad-Ata toxin-antitoxin system |
166 | 239 | COG4680 | J V | mRNA-degrading endonuclease (mRNA interferase) HigB, toxic component of the HigAB toxin-antitoxin module |
145 | 180 | COG4691 | V | Plasmid stability protein StbC1, contains ribbon-helix-helix domain |
41 | 47 | COG4734 | V | Antirestriction protein ArdA |
183 | 283 | COG4767 | V | Glycopeptide antibiotics resistance protein |
160 | 188 | COG4823 | V | Abortive infection bacteriophage resistance protein |
144 | 146 | COG4832 | V T | Cyclopropanoid cyclopropyl hydrolase, GyrI-like domain |
147 | 418 | COG4842 | V | Secreted virulence factor YukE/EsxA, WXG100 family |
123 | 145 | COG4845 | V | Chloramphenicol O-acetyltransferase |
236 | 325 | COG5340 | V | Abortive phage infection protein AbiEi, antitoxin conponent of an AbiEi-AbiEii TA system |
92 | 134 | COG5428 | V | Predicted antitoxin component YuzE of a toxin-antitoxin system, DUF2283 family |
127 | 142 | COG5441 | V | ATP-binding helicase-inhibiting domain, Tm-1/UPF0261 family |
22 | 71 | COG5444 | V | Predicted ribonuclease, toxin component of the YeeF-YezG toxin-antitoxin module |
201 | 292 | COG5499 | V | Antitoxin component HigA of the HigAB toxin-antitoxin module, contains an N-terminal HTH domain |
61 | 61 | COG5503 | K V | DNA-dependent RNA polymerase auxiliary subunit epsilon |
122 | 178 | COG5551 | V | CRISPR/Cas system endoribonuclease Cas6, RAMP superfamily |
156 | 212 | COG5606 | V | Antitoxin component of the Tad-Ata toxin-antitoxin system, contains XRE-type HTH domain |
131 | 150 | COG5608 | V | Dessication stress tolerance protein, LEA/WHy domain |
153 | 211 | COG5642 | V | Predicted antitoxin component of a toxin-antitoxin system, contains Xre-type HTH domain |
169 | 238 | COG5654 | V | Predicted toxin component of a toxin-antitoxin system, contains RES domain |
122 | 132 | COG5658 | V | Bacterial immunity/signal transduction membrane protein SdpI, SdpI/YbgB/DUF1648 family |
25 | 25 | COG5930 | V | CRISPR-Cas system type I-D effector complex large subunit Cas10d/Csc3, contains HD superfamily nuclease domain |
6 | 6 | COG5931 | V | CRISPR-Cas system type-V protein Cas12a |
49 | 54 | COG5932 | V | CRISPR-Cas type I-F system-associated endonuclease/helicase Cas3f, fused to Cas2 domain |
50 | 52 | COG5933 | V | CRISPR-Cas system type I-F effector complex subunit Cas5f/Csy2, RAMP superfamily |
134 | 149 | COG5934 | V | CRISPR-Cas system endoribonuclease Cas6e, RAMP superfamily |
49 | 50 | COG5935 | V | CRISPR-Cas system endoribonuclease Cas6f/Csy4, RAMP superfamily |
50 | 52 | COG5936 | V | CRISPR-Cas system type I-F effector complex subunit Cas7f/Csy3, RAMP superfamily |
8 | 8 | COG5937 | V | CRISPR-Cas system type I-A effector complex large subunit Cas8a4 |
71 | 78 | COG5938 | V | CRISPR-Cas system type I-B effector complex large subunit Cas8b1 |
42 | 44 | COG5939 | V | CRISPR-Cas system type I-B effector complex large subunit Cas8b2 |
9 | 10 | COG5940 | V | CRISPR-Cas system type I-B effector complex large subunit Cas8b3 |
117 | 121 | COG5941 | V | CRISPR-Cas system type I-C effector complex large subunit Cas8c |
129 | 142 | COG5942 | V | CRISPR-Cas system type I-E effector complex large subunit Cas8e |
50 | 53 | COG5943 | V | CRISPR-Cas system type I-F effector complex large subunit Cas8f |
24 | 28 | COG5944 | V | CRISPR-Cas system type I-G effector complex large subunit Cas8g1 |
24 | 29 | COG5945 | V | CRISPR-Cas system type I-G effector complex subunit Csb1, RAMP superfamily Cas7 group |
25 | 34 | COG5946 | V | CRISPR-Cas system type I-G effector complex subunit Csb5, RAMP superfamily Cas5 group |
34 | 35 | COG5947 | V | CRISPR-Cas system type I-D effector complex subunit Csc1, RAMP superfamily Cas5 group |
43 | 44 | COG5948 | V | CRISPR-Cas system type I-D effector complex subunit Csc2, RAMP superfamily Cas7 group |
128 | 135 | COG5949 | V | CRISPR-Cas system type I-E effector complex small subunit Cse2 |
42 | 47 | COG5950 | V | CRISPR-Cas system type II-D effector complex subunit Csx10, RAMP superfamily Cas5 group |