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Debunking the Dopamine Detox Trend
The fad of temporarily fasting from pleasurable activities likely won’t “reset” dopamine levels and doesn’t accurately reflect this molecule’s nuanced functions.
Read more at The Scientist
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Research findings and data from the National Library of Medicine
PubMed articles
Religious fasting and its impacts on individual, public, and planetary health: Fasting as a "religious health asset" for a healthier, more equitable, and sustainable society
Religious fasting is practiced by people of all faiths, including Christianity, Islam, Buddhism, Jainism, as well as Hinduism, Judaism, and Taoism. Individual/clinical, p …
Responses of midbrain dopamine neurons to behavioral trigger stimuli in the monkey
Destruction of the midbrain dopamine (DA) system in Parkinsonian man and experimental animals leads to deficits in initiation of behavior, motor performance, and cognitiv …
Dopamine reward prediction error coding
Reward prediction errors consist of the differences between received and predicted rewards. They are crucial for basic forms of learning about rewards and make us strive …
Responses of monkey dopamine neurons during learning of behavioral reactions
1. Previous studies have shown that dopamine (DA) neurons respond to stimuli of behavioral significance, such as primary reward and conditioned stimuli predicting reward …
Molecular Regulation in Dopaminergic Neuron Development. Cues to Unveil Molecular Pathogenesis and Pharmacological Targets of Neurodegeneration
The relatively few dopaminergic neurons in the mammalian brain are mostly located in the midbrain and regulate many important neural functions, including motor integratio …
Dopamine transients do not act as model-free prediction errors during associative learning
Dopamine neurons are proposed to signal the reward prediction error in model-free reinforcement learning algorithms. This term represents the unpredicted or 'excess' valu …
Classification of Midbrain Dopamine Neurons Using Single-Cell Gene Expression Profiling Approaches
Dysfunctional dopamine (DA) signaling has been associated with a broad spectrum of neuropsychiatric disorders, prompting investigations into how midbrain DA neuron hetero …
Unique functional responses differentially map onto genetic subtypes of dopamine neurons
Dopamine neurons are characterized by their response to unexpected rewards, but they also fire during movement and aversive stimuli. Dopamine neuron diversity has been ob …
Single-cell genomic profiling of human dopamine neurons identifies a population that selectively degenerates in Parkinson's disease
The loss of dopamine (DA) neurons within the substantia nigra pars compacta (SNpc) is a defining pathological hallmark of Parkinson's disease (PD). Nevertheless, the mole …
Cocaine Self-Administration Experience Induces Pathological Phasic Accumbens Dopamine Signals and Abnormal Incentive Behaviors in Drug-Abstinent Rats
Relapsing to drug abuse despite periods of abstinence and sincere attempts to quit is one of the most pernicious facets of addiction. Unfortunately, little is known about …
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