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News: Gene variation may protect against... (NIH Research Matters) - Behind the headlines

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Media coverage of health and science topics

NIH Research Matters Nov. 26, 2019

Gene variation may protect against Alzheimer’s disease

A woman with an inherited condition that causes early-onset Alzheimer’s disease but who didn’t experience cognitive decline until her 70s appeared to be protected by a rare mutation.

Read more at NIH Research Matters

Behind the headlines

Research findings and data from the National Library of Medicine

PubMed articles

Nat Med NOV. 4, 2019

Resistance to autosomal dominant Alzheimer's disease in an APOE3 Christchurch homozygote: a case report

JF Arboleda-Velasquez et al

We identified a PSEN1 (presenilin 1) mutation carrier from the world's largest autosomal dominant Alzheimer's disease kindred, who did not develop mild cognitive impairme …

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The New York Times DEC. 11, 2020

In Life, She Defied Alzheimer’s. In Death, Her Brain May Show How. (Published 2020)

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Man who defied genetics for decades may hold a clue to preventing Alzheimer's, scientists say | CNN

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NIH News Releases NOV. 4, 2019

Unique case of disease resistance reveals possible Alzheimer’s treatment

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NIH Research Matters SEPT. 1, 2020

Blood tests show promise for early Alzheimer’s diagnosis

Blood levels of a protein called ptau217 were associated with damage to the brain caused by Alzheimer’s disease, and may one day help diagnose disease before symptoms appear.

NIH Research Matters MAY 19, 2020

Alzheimer’s gene contributes to blood-brain barrier breakdown

Damage to the blood-brain barrier may contribute to the development of Alzheimer’s dementia in people carrying a high-risk gene variation.