Human-goat chimerism achieved by transplanting human CD34+Lin- cord blood cells into fetal goats. Markers indicate human genes expressed in goat liver and blood. Human/goat hematopoietic stem cell (HSC) xenogeneic model allows analysis of HSC transplantation, expansion and differentiation in vivo.
GPL96:
[HG-U133A] Affymetrix Human Genome U133A Array
Citation:
Zeng F, Chen MJ, Baldwin DA, Gong ZJ et al. Multiorgan engraftment and differentiation of human cord blood CD34+ Lin- cells in goats assessed by gene expression profiling. Proc Natl Acad Sci U S A 2006 May 16;103(20):7801-6. PMID: 16682618
