Structural bone autograft and allograft comparison
Summary:
Expression profiling of autografted and allografted femurs of 8 week old C57BL/6 animals. Allografts obtained from ICR animals and grafted onto C57BL/6 femurs. Bone remodeling and vascularization in autografts is superior to that in allografts. Results identify genes important in autograft healing.
Ito H, Koefoed M, Tiyapatanaputi P, Gromov K et al. Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy. Nat Med 2005 Mar;11(3):291-7. PMID: 15711561