Stearoyl-CoA desaturase 1 null mutation effect on liver
Summary:
Analysis of liver of 6 week old stearoyl-CoA desaturase 1 (SCD1) knockout females. SCD1 is a lipogenic enzyme that catalyzes the synthesis of monosaturated fatty acids. SCD1 null mutants have reduced body adiposity, increased insulin sensitivity, and are resistant to diet-induced weight gain.
Ntambi JM, Miyazaki M, Stoehr JP, Lan H et al. Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Proc Natl Acad Sci U S A 2002 Aug 20;99(17):11482-6. PMID: 12177411
