Akt kinase constitutive activation effect on embryonic stem cells
Summary:
Analysis of embryonic stem (ES) cells expressing a myristoylated, active form of Akt (myr-Akt) kinase. Myr-Akt expression maintains pluripotency of ES cells even in the absence of leukemia inhibitory factor (LIF). Results demonstrate Akt signaling is sufficient to maintain ES cell pluripotency.
GPL81:
[MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array
Citation:
Watanabe S, Umehara H, Murayama K, Okabe M et al. Activation of Akt signaling is sufficient to maintain pluripotency in mouse and primate embryonic stem cells. Oncogene 2006 May 4;25(19):2697-707. PMID: 16407845
