Analysis of hypoxia-inducible factor-1alpha (HIF-1alpha) null mutant hepatocytes subjected to hypoxic conditions for 8 hours. The HIF-1alpha transcription factor is a key regulator of oxygen homeostasis. Results provide insight into hepatocyte gene expression changes induced by short-term hypoxia.
GPL81:
[MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array
Citation:
Allen JW, Khetani SR, Johnson RS, Bhatia SN. In vitro liver tissue model established from transgenic mice: role of HIF-1alpha on hypoxic gene expression. Tissue Eng 2006 Nov;12(11):3135-47. PMID: 17518628