Telomerase reverse transcriptase immortalizing effect on fibroblasts and endothelial cells: time-course
Summary:
Analysis of normal fibroblasts and endothelial cells, at various population doubling levels (PDLs), following human telomerase reverse transcriptase (hTERT) transfection. hTERT mediates cellular immortalization. Results identify cell-type specific transcriptional responses during immortalization.
Hiyama K, Otani K, Ohtaki M, Satoh K et al. Differentially expressed genes throughout the cellular immortalization processes are quite different between normal human fibroblasts and endothelial cells. Int J Oncol 2005 Jul;27(1):87-95. PMID: 15942647
