Alpha-tropomyosin mutant models of familial cardiac hypertrophy
Summary:
Analysis of ventricles of mutants with mild ventricular disorganization and limited hypertrophy or with severe hypertrophy and fibrosis. Mutants possess familial cardiac hypertrophy (CH) associated mutations in alpha-tropomyosin. Results provide insight into mechanisms that mediate the onset of CH.
Rajan S, Williams SS, Jagatheesan G, Ahmed RP et al. Microarray analysis of gene expression during early stages of mild and severe cardiac hypertrophy. Physiol Genomics 2006 Nov 27;27(3):309-17. PMID: 16882888
