CH1 domain deletion, p300 and CBP heterozygous null mutant hypoxic fibroblasts response to trichostatin A
Summary:
Analysis of trichostatin A (TSA)-treated hypoxic fibroblasts with deletions in CH1 domains of p300 and CBP, and a p300 or CBP allele knockout. TSA is a histone deacetylase inhibitor. Results provide insight into the role of deacetylase activity in CH1-independent hypoxia inducible transcription.
Kasper LH, Boussouar F, Boyd K, Xu W et al. Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression. EMBO J 2005 Nov 16;24(22):3846-58. PMID: 16237459
