Transgenic T-cell receptor model of tolerant CD8+ T cells
Summary:
Analysis of tolerant, naïve, and memory CD8+ T cells purified from TCRxGag transgenics. T cell tolerance to self-proteins prevents autoimmunity but impedes the response to tumor-associated antigens. Results provide insight into the feasibility of rescuing tolerant cells for tumor immunotherapy.
Teague RM, Sather BD, Sacks JA, Huang MZ et al. Interleukin-15 rescues tolerant CD8+ T cells for use in adoptive immunotherapy of established tumors. Nat Med 2006 Mar;12(3):335-41. PMID: 16474399
