Analysis of primary breast carcinoma tumors from 50 patients who received breast-conserving therapy (BCT). 19 patients subsequently developed a local recurrence of the carcinoma. 9 recurrent tumors also examined. Compared to mastectomy, BCT is associated with a higher rate of local recurrence.
Kreike B, Halfwerk H, Kristel P, Glas A et al. Gene expression profiles of primary breast carcinomas from patients at high risk for local recurrence after breast-conserving therapy. Clin Cancer Res 2006 Oct 1;12(19):5705-12. PMID: 17020974