Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy: dendritic cells
Summary:
Analysis of in vitro differentiated dendritic cells (DCs) from patients with PLOSL, an early onset dementia with bone cysts caused by mutations in DAP12 and TREM2 genes which encode important signaling molecules in DCs. Results provide further insight into mechanisms underlying PLOSL pathogenesis.
GPL96:
[HG-U133A] Affymetrix Human Genome U133A Array
Citation:
Kiialainen A, Veckman V, Saharinen J, Paloneva J et al. Transcript profiles of dendritic cells of PLOSL patients link demyelinating CNS disorders with abnormalities in pathways of actin bundling and immune response. J Mol Med (Berl) 2007 Sep;85(9):971-83. PMID: 17530208
