Estrogen effect on estrogen receptors alpha and beta single knockouts: aorta
Summary:
Analysis of estrogen receptor alpha or beta null aortas of ovariectomized animals treated with estrogen. Estrogen is important in vascular tone regulation and in cardiovascular disease pathophysiology. Results provide insight into the mechanisms mediating the effects of estrogen in blood vessels.
O'Lone R, Knorr K, Jaffe IZ, Schaffer ME et al. Estrogen receptors alpha and beta mediate distinct pathways of vascular gene expression, including genes involved in mitochondrial electron transport and generation of reactive oxygen species. Mol Endocrinol 2007 Jun;21(6):1281-96. PMID: 17374850
