Antifungal compound sampangine effect on Saccharomyces cerevisiea
Summary:
Analysis of Saccharomyces cerevisiae cells treated with the antifungal compound sampangine. Sampangine exhibits strong inhibitory activity against opportunistic fungal pathogens such as Candida albicans. Using S. cerevisiae as a model, results provide insight into sampangine's mechanism of action.
Agarwal AK, Xu T, Jacob MR, Feng Q et al. Role of heme in the antifungal activity of the azaoxoaporphine alkaloid sampangine. Eukaryot Cell 2008 Feb;7(2):387-400. PMID: 18156292