Peroxisome proliferator-activated receptor alpha deficiency effect on phthalate-exposed liver
Summary:
Analysis of livers from peroxisome proliferator-activated receptor (PPAR) α-null animals exposed to the plasticizer di-(2-ethylhexyl) phthalate (DEHP). DEHP increases liver tumors in the absence of PPARα. Results provide insight into DEHP-induced transcriptional changes independent of PPARα.
Ren H, Aleksunes LM, Wood C, Vallanat B et al. Characterization of peroxisome proliferator-activated receptor alpha--independent effects of PPARalpha activators in the rodent liver: di-(2-ethylhexyl) phthalate also activates the constitutive-activated receptor. Toxicol Sci 2010 Jan;113(1):45-59. PMID: 19850644