A2780 epithelial ovarian cancer cell line with acquired platinum resistance
Summary:
Analysis of a cisplatin-resistant, A2780 cell line derived from parental (drug-sensitive) A2780 cells after 5 rounds of drug selection. Resistance to platinum (Pt)-based drugs occurs in the large majority of initially responsive tumors. Results provide insight into molecular basis of Pt resistance.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Li M, Balch C, Montgomery JS, Jeong M et al. Integrated analysis of DNA methylation and gene expression reveals specific signaling pathways associated with platinum resistance in ovarian cancer. BMC Med Genomics 2009 Jun 8;2:34. PMID: 19505326
