Analysis of regulatory, pathogenic, and functionally neutral control T cells. Autoantigen-specific regulatory T cells (Tregs) play important roles in regulating immune responses and enhancing inhibition of type 1 diabetes. Results provide insight into molecular mechanisms modulating Treg function.
Qin H, Wang Z, Du W, Lee WH et al. Killer cell Ig-like receptor (KIR) 3DL1 down-regulation enhances inhibition of type 1 diabetes by autoantigen-specific regulatory T cells. Proc Natl Acad Sci U S A 2011 Feb 1;108(5):2016-21. PMID: 21245333