Mixed lineage leukemia fusion protein induction of acute leukemia: bone marrow cells
Summary:
Analysis of bone marrow of C57BL6 mice injected with AAF4.MLL-transduced or AF4.MLL/MLL.AF4-transduced leukemic cells. MLL fusion proteins initiate malignant transformation leading to the development of acute leukemia. Results provide insight into the leukemogenic properties of MLL fusion proteins.
Bursen A, Schwabe K, Rüster B, Henschler R et al. The AF4.MLL fusion protein is capable of inducing ALL in mice without requirement of MLL.AF4. Blood 2010 Apr 29;115(17):3570-9. PMID: 20194896
