DataSet Record GDS4175: Expression Profiles Data Analysis Tools Sample Subsets
Title: Imatinib effect on Philadelphia chromosome positive acute lymphoblastic leukemia cells
Cluster AnalysisGDS4175 Cluster Image
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Summary: Analysis of Ph+ ALL cell lines (BV-173, NALM-1, SUP-B15, and TOM1) treated with tyrosine kinase inhibitor (TKI) imatinib. Ph encodes oncogenic BCR-ABL1 tyrosine kinase, which defines a subset of ALL with an unfavorable prognosis. Results provide insight into TKI resistance mechanisms in Ph+ ALL.
Organism: Homo sapiens
Platform: GPL571: [HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Citation:
  • Duy C, Hurtz C, Shojaee S, Cerchietti L et al. BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition. Nature 2011 May 19;473(7347):384-8. PMID: 21593872
Reference Series: GSE23743 Sample count: 8
Value type: count Series published: 2010/09/10