Clear-cell renal cell carcinoma tumors and tumorgrafts deficient for tumor suppressor BAP1 or PBRM1
Summary:
Analysis of BAP1- and PBRM1-deficient ccRCC primary tumors, tumors growing in immunodeficient mice (tumorgrafts), and matched normal kidney cortices. BAP1 loss, but not PBRM1 loss, is associated with high-grade tumors. Results provide insight into molecular classification of RCC subtypes.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citations:
Peña-Llopis S, Vega-Rubín-de-Celis S, Liao A, Leng N et al. BAP1 loss defines a new class of renal cell carcinoma. Nat Genet 2012 Jun 10;44(7):751-9. PMID: 22683710
Peña-Llopis S, Brugarolas J. Simultaneous isolation of high-quality DNA, RNA, miRNA and proteins from tissues for genomic applications. Nat Protoc 2013 Nov;8(11):2240-55. PMID: 24136348
