AP1510, TGFα or heregulin ligand effect on MCF10 mammary epithelial cells expressing HER2-FKBP-HA chimeric receptors
Summary:
Analysis of mammary epithelial MCF10A/HER2/FKBP/HA cells treated with AP1510 to induce the chimeric HER2-FKBP molecule to homodimerize, or with TGFα or heregulin to induce heterodimerization with EGFR or HER3. Results provide insight into signaling events following HER2 receptor dimerization.
GPL6244:
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]
Citation:
Ghosh R, Narasanna A, Wang SE, Liu S et al. Trastuzumab has preferential activity against breast cancers driven by HER2 homodimers. Cancer Res 2011 Mar 1;71(5):1871-82. PMID: 21324925
