Lung epithelium response to fungal allergen Alternaria
Summary:
Analysis of bronchial brushings of lung epithelium from C57BL/6 females after Alternaria challenge. Alternaria allergen is associated with severe asthma, including life-threatening exacerbations. Results provide insight into the molecular basis of the acute innate airway response to Alternaria.
Doherty TA, Khorram N, Sugimoto K, Sheppard D et al. Alternaria induces STAT6-dependent acute airway eosinophilia and epithelial FIZZ1 expression that promotes airway fibrosis and epithelial thickness. J Immunol 2012 Mar 15;188(6):2622-9. PMID: 22327070
