Analysis of leukemic stem cells (LSCs), with granulocyte monocyte precursor (GMP) surface phenotype, from a MOZ-TIF2 model of leukemia (L-GMPs) and their normal GMP counterparts. Results provide insight into molecular mechanisms underlying the evolution and maintenance of LSCs in leukemogenesis.
Kvinlaug BT, Chan WI, Bullinger L, Ramaswami M et al. Common and overlapping oncogenic pathways contribute to the evolution of acute myeloid leukemias. Cancer Res 2011 Jun 15;71(12):4117-29. PMID: 21505102