Progeroid and revertant phenotypes in primary dermal fibroblast cell line GM00038
Summary:
Analysis of fibroblasts expressing progerin (the mutant lamin A associated with progeria) or elevated levels of wildtype prelamin A. Cells subsequently reverted towards normal by farnesyltransferase inhibitor (FTI) or ZMPSTE24 treatment. Results identify potential effector of lamin A dysfunction.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Candelario J, Chen LY, Marjoram P, Reddy S et al. A filtering strategy identifies FOXQ1 as a potential effector of lamin A dysfunction. Aging (Albany NY) 2012 Aug;4(8):567-77. PMID: 22948034
