Tuberous sclerosis complex 1 deficient naïve CD4 and CD8 T cells
Summary:
Analysis of naïve CD4 and CD8 T cells deficient for Tuberous sclerosis complex 1 (Tsc1). Tsc1 tumor suppressor is an mTOR signaling modulator involved in naive T cell quiescence and immune homeostasis regulation. Results identify a Tsc1-dependent gene signature in naive T cells.
Yang K, Neale G, Green DR, He W et al. The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function. Nat Immunol 2011 Jul 17;12(9):888-97. PMID: 21765414
