Atypical neuroleptic quetiapine effect on brain: dose response
Summary:
Analysis of frontal cortex and striatum from males treated with quetiapine at doses of 10 or 100 mg/kg, twice a day for 28 days. Quetiapine has pharmacological actions distinct from classic neuroleptics. Results provide insight into molecular basis of the unique therapeutic profile of quetiapine.
Kondo MA, Tajinda K, Colantuoni C, Hiyama H et al. Unique pharmacological actions of atypical neuroleptic quetiapine: possible role in cell cycle/fate control. Transl Psychiatry 2013 Apr 2;3:e243. PMID: 23549417
